<b>Correlation between allergic conjunctivitis and changes in tear film lipid layer and meibomian gland function</b>

Objective: To investigate the correlation between allergic conjunctivitis (AC) and changes in tear film lipid layer (TFLL) and meibomian gland (MG) function. Methods: The clinical data of 96 patients with AC treated at our hospital from June 2022 to March 2023 and 72 healthy individuals who underwent physical examination in our hospital during the same period were analyzed retrospectively. Among them, 96 patients with AC were included in the study group, while 72 healthy individuals were included in the control group. Eyes selected for study from participants were the left eyes or one single eye that met the selection criteria. The TFLL thickness, MG score, MG secretion character score, and ocular surface disease index (OSDI) score were compared between the study group and healthy control group. Patients in the study group were further categorized into a mild group and a severe group based on their OSDI scores. The TFLL thickness, MG score, and MG secretion character score were then compared between these two groups. Additionally, the correlations of TFLL thickness, MG score, and MG secretion character score with OSDI were analyzed. The diagnostic value of TFLL, MG score, MG secretion character score and combination of the three in diagnosing AC was evaluated. Results: Compared to the control group, the study group showed significantly thinner TFLL and got significantly higher MG score, MG secretion character score and OSDI score (P&lt;0.0001). The TFLL thickness showed a negative correlation with OSDI score (r=-0.7149; P&lt;0.0001). Conversely, both MG score (r=0.5585; P&lt;0.0001) and MG secretion score (r=0.4390; P&lt;0.0001) demonstrated a positive correlation with OSDI score. Furthermore, the mild group showed significantly thicker TFLL than the severe group (P&lt;0.0001), and got significantly lower MG score and MG secretion score than the severe group (P&lt;0.0001). The area under the curve (AUC) values of TFLL thickness, MG score, and MG secretion score in the diagnosis of AC were 0.869, 0.834, and 0.738, respectively, and the AUC of the combination of these three in diagnosing AC was 0.922. Conclusion: AC is strongly bound up with TFLL and MG function. The combination of TFLL, MG score, and MG secretion score can be adopted for effective diagnosis of AC.研究目的：探讨过敏性结膜炎（allergic conjunctivitis, AC）与泪膜脂质层（tear film lipid layer, TFLL）及睑板腺（meibomian gland, MG）功能变化的相关性。 方法：回顾性分析2022年6月至2023年3月于本院就诊的96例AC患者及同期本院体检的72名健康个体的临床资料。将96例AC患者纳入研究组，72名健康个体纳入对照组。研究选取受试者符合纳入标准的左眼或单眼作为观察眼。比较研究组与健康对照组的泪膜脂质层厚度、睑板腺评分、睑板腺分泌物性状评分及眼表疾病指数（ocular surface disease index, OSDI）评分。进一步根据OSDI评分将研究组患者分为轻度组与重度组，比较两组的泪膜脂质层厚度、睑板腺评分及睑板腺分泌物性状评分。此外，分析泪膜脂质层厚度、睑板腺评分、睑板腺分泌物性状评分与OSDI评分的相关性。评估泪膜脂质层、睑板腺评分、睑板腺分泌物性状评分及三者联合对AC的诊断价值。 结果：与对照组相比，研究组患者的泪膜脂质层厚度显著变薄，睑板腺评分、睑板腺分泌物性状评分及OSDI评分均显著升高（P<0.0001）。泪膜脂质层厚度与OSDI评分呈负相关（r=-0.7149；P<0.0001）；反之，睑板腺评分（r=0.5585；P<0.0001）与睑板腺分泌物评分（r=0.4390；P<0.0001）均与OSDI评分呈正相关。此外，轻度组的泪膜脂质层厚度显著高于重度组（P<0.0001），睑板腺评分及睑板腺分泌物评分均显著低于重度组（P<0.0001）。泪膜脂质层厚度、睑板腺评分、睑板腺分泌物性状评分诊断AC的受试者工作特征曲线下面积（area under the curve, AUC）分别为0.869、0.834和0.738，三者联合诊断AC的AUC为0.922。 结论：AC与泪膜脂质层及睑板腺功能密切相关。联合检测泪膜脂质层、睑板腺评分及睑板腺分泌物性状评分可有效辅助AC的临床诊断。

搜集汇总

背景与挑战

背景概述

该数据集聚焦于过敏结膜炎与泪膜脂质层和睑板腺功能变化之间的相关性研究，通过回顾性分析168名参与者的临床数据，发现过敏结膜炎患者在这些指标上存在显著差异，并验证了组合诊断的有效性。数据集发布于2023年，属于临床心理学领域，提供原始数据用于进一步分析。