Iridium Cyclooctene Complex That Forms a Hyperpolarization Transfer Catalyst before Converting to a Binuclear C–H Bond Activation Product Responsible for Hydrogen Isotope Exchange
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资源简介：
[IrCl(COE)2]2 (1) reacts with pyridine (py) and H2 to form crystallographically characterized IrCl(H)2(COE)(py)2 (2). 2 undergoes
py loss to form 16-electron IrCl(H)2(COE)(py) (3), with equivalent hydride ligands. When this reaction is studied
with parahydrogen, 1 efficiently achieves hyperpolarization
of free py (and nicotinamide, nicotine, 5-aminopyrimidine, and 3,5-lutudine)
via signal amplification by reversible exchange (SABRE) and hence
reflects a simple and readily available precatayst for this process. 2 reacts further over 48 h at 298 K to form crystallographically
characterized (Cl)(H)(py)(μ-Cl)(μ-H)(κ-μ-NC5H4)Ir(H)(py)2 (4). This
dimer is active in the hydrogen isotope exchange process that is used
in radiopharmaceutical preparations. Furthermore, while [Ir(H)2(COE)(py)3]PF6 (6) forms
upon the addition of AgPF6 to 2, its stability
precludes its efficient involvement in SABRE.
创建时间：
2016-12-27
