Text S1 - Molecular Predictors of 3D Morphogenesis by Breast Cancer Cell Lines in 3D Culture

This file contains supplementary materials. Section 1 shows how pure thresholding fails in delineating foreground and background. Section 2 provides a summary of Zernike polynomial for representing morphometric traits. Section 3 summarizes background on non-linear regression methods for identifying molecular targets. Section 4 provides comparative analysis with the Gene Set Enrichment Analysis (GSEA). Section 5 outlines the details of validation protocol that includes quantitative image analysis. (0.78 MB PDF)