Crystal Structure of human PARP-1 ART domain bound to inhibitor UTT57
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Crystal Structure of human PARP-1 ART domain bound to inhibitor UTT57 Descriptor: 2-{[3-fluoro-4-(1H-tetrazol-5-yl)phenyl]methyl}-3-hydroxy-1-benzofuran-7-carboxamide, DIMETHYL SULFOXIDE, Poly [ADP-ribose] polymerase 1, ... Authors: Langelier, M.F, Pascal, J.M. Deposit date: 2019-01-23 Release date: 2019-08-14 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity. J.Med.Chem., 62, 2019
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2019-01-23
