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The yeast and human FACT complexes resolve R-loop-mediated transcription-replication conflicts

ChEBI2014-03-17 更新2026-07-21 收录

基因组稳定性

转录-复制冲突调控

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-51653 数据链接链接失效反馈

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The yeast and human FACT complexes resolve R-loop-mediated transcription-replication conflicts

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创建时间：

2014-03-17

表观遗传调控

基因组稳定性

Histone H3.3 is a highly conserved histone H3 replacement variant in metazoans, and has been implicated in many important biological processes including cell differentiation and reprogramming. Germlin

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MRE11 proximal polyadenylation site-mediated looping impacts transcription and genomic stability

基因组稳定性

转录调控机制

Raw data for Huang et al.,

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BLM prevents instability of structure-forming DNA sequences at common fragile sites

基因组稳定性

DNA修复

Genome instability often arises at common fragile sites (CFSs) leading to cancer-associated chromosomal rearrangements. However, the underlying mechanisms of how CFS protection is achieved is not well

Figshare2018-12-11 更新50

SIRT7 tethering of L1 elements to the nuclear lamina mediates their transcriptional repression

基因组稳定性

表观遗传调控

Long interspersed elements-1 (LINE-1, L1) are retrotransposons that hold the capacity of selfpropagation in the genome with potential mutagenic outcomes. How somatic cells restrict L1 activity and how

干细胞与再生医学数据中心2022-02-20 更新70

TDP-43 safeguards the embryo genome from L1 retrotransposition. TDP-43 safeguards the embryo genome from L1 retrotransposition

逆转录转座子抑制剂

基因组稳定性

We report that TAR DNA binding protein 43 (TDP-43), mutations in which constitute a major risk factor for amyotrophic lateral sclerosis (ALS), inhibits L1 retrotransposition in mouse embryonic stem ce

NIAID Data Ecosystem50

The yeast and human FACT complexes resolve R-loop-mediated transcription-replication conflicts

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