Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA)

The OPPERA project has two sub-studies investigating effects of genetic, physiological, psychological and clinical factors on the risk of developing painful temporomandibular disorder (TMD). OPPERA I baseline case-control study of chronic TMJD (dbGaP study accession phs000762). This sub-study uses a case-control study design to investigate characteristics associated with chronic TMD. The parent OPPERA phenotype file contains an indicator variable (PHASE1CASECONTROL) identifying participants in this sub-study. Data users should use the relevant case-classification variable (CHRNONICTMDCASE) and apply statistical methods appropriate for case-control studies when analyzing TMJD in this sub-study. OPPERA I prospective cohort for first onset of TMJD (dbGaP study accession phs000850). This sub-study uses a prospective cohort study design to investigate characteristics that predict risk of developing first-onset TMD. The parent OPPERA phenotype file contains an indicator variable (PROSPECTIVECOHORT) identifying participants in this sub-study. Data users should use the relevant case-classification variable (INCIDENTCASE) and the relevant time-in-study variable (FOLLOWUPYEARS) when analyzing TMJD in this sub-study. It is recommended that data users apply statistical methods appropriate for cohort studies of a dynamic population (for example, Cox regression models, where INCIDENTCASE is the censoring variable and FOLLOWUPYEARS is time in study). ]]>
ParentOPPERA_23DEC14 CodebookInclusion criteria were all three of: Age 18-44 years Planning on living in the area for the next two years Fluent in written and spoken English. Exclusion criteria were any one of 13 conditions: Traumatic facial injury or surgery on the face or jaw within the six months preceding enrollment Currently receiving orthodontic treatment Pregnant or nursing Kidney failure or renal dialysis Heart disease or heart failure Chronic respiratory disease that is not controlled with medication Hypertension that is not controlled with medication Epilepsy or medication to control grand mal seizures Hyperthyroidism Diabetes that is not controlled with medication or diet Drug or alcohol abuse Psychiatric disorders or conditions that have required hospitalization Chemotherapy or radiation therapy. ]]>
The OPPERA project began in 2006 with enrollment of participants into two studies at four U.S. study sites: Baltimore, MD; Buffalo, NY; Chapel Hill, NC; and Gainesville, FL. In 2012, the National Institute of Dental and Craniofacial Research (NIDCR) awarded funding to support the study for an additional five year period.]]>