MDT-15 depletion compromises induction of select detoxification genes by the toxins fluoranthene (FLA) and β-naphthoflavone (NF).

Values represent fold-inductions of indicated detoxification genes relative to DMSO-treated control(RNAi) worms. Each value represents the average±SEM calculated from three independent worm growths and RNA isolations from L4 stage animals, as determined by qPCR; mRNA levels were normalized to act-1. Columns on the right indicate the fold-induction by toxins vs. DMSO in the same RNAi condition. RNAi depletion of mdt-15 compromises mRNA expression of select genes; genes whose induction by toxins is compromised at least two-fold are highlighted bold.