A type 4 resistant potato starch alters the cecal microbiome and gene expression in mice fed a Western diet based on NHANES data

Type 4 RSs (RS4) are chemically modified starches not normally found in nature but have become a popular food additive as their addition increases fiber content, as defined by the FDA. To explore the effects of feeding on the microbiome and gene expression, we fed different levels of Versifibe 1490TM, a phosphorylated and cross-linked potato starch, to mice and looked for changes in the cecal microbiota and SCFA production and gene expression in the cecum and colon.

第4型化学改性淀粉（RS4）并非自然界中固有，但因其添加能够提高纤维含量（根据美国食品药品监督管理局的定义）而成为了一种流行的食品添加剂。为了探究喂养对微生物组和基因表达的影响，我们向小鼠投喂不同剂量的Versifibe 1490TM（一种磷酸化和交联的马铃薯淀粉），并观察盲肠微生物群、短链脂肪酸（SCFA）生成以及盲肠和结肠中的基因表达的变化。