This study presents a mutation profile analysis of 3,252 SARS-CoV-2 genomes collected between January and early May 2025 , focusing on non-structural proteins (NSP7, NSP8, NSP12, and NSP
Regional mutation density (RMD) signatures obtained after appling NMF into a matrix of mutation density across 1Mb windows along the genome for 4221 tumor samples. The values provided (NMF weights) re
Supplementary Table 3: Exome-wide MTR scores. Expected and observed counts of missense and synonymous variants observed in each 31-codon window centered on possible missense variants exome-wide using
Hydrolases are a critical component for modern chemical, pharmaceutical, and environmental sciences. Identifying mutations that enhance catalytic efficiency presents a roadblock to design and to disco
