Profiling of a series of triple positive (CD10+BCL6+MUM1+) diffuse large B-cell lymphoma cases

Gene expression profiling (GEP) divides DLBCL according to the cell of origin into GCB, ABC and unclassifiable, exhibiting different mutational profiles. The Hans algorithm, a surrogate of GEP, classifies cases expressing CD10, BCL6 and MUM1 as GCB but it is not clear whether all these cases correspond to GCB-type. Accordingly, LBCL with IRF4 rearrangement usually expresses GCB phenotype (CD10+, BCL6+) together with strong MUM1/IRF4. The aim of this study was to characterize the molecular heterogeneity of DLBCL triple positive (CD10+ BCL6+MUM1+) in adults. CN alterations were examined in 9 out of 13 cases with available material and IRF4 rearrangement and/or IRF4 mutations using OncoScan platform