Insights from a Methylome-Wide Association Study of Antidepressant Exposure

Results datasets from the paper: 

Insights from a Methylome-Wide Association Study of Antidepressant Exposure

Methylome-wide association study (MWAS) summary statistics: 

All individuals: 

MWAS of prescription-derived antidepressant exposure (n = 7,951): 

 GRM_unadjusted_antidep_pheno1_clean_appt_MOA_ORM_residph_standard_06_10.moa

MWAS of self-reported antidepressant exposure (n = 16,531):

 GRM_unadjusted_selfrep_pheno3_MOA_ORM_residph_standard_06_10.moa

Individuals with a lifetime status of Major Depressive Disorder (MDD, MDD-subgroup): 

MWAS of prescription-derived antidepressant exposure (n = 792)

GRM_unadjusted_antidep_pheno2_clean_appt_MOA_ORM_residph_standard_06_10.moa

MWAS of self-reported antidepressant exposure (n = 2,268):

GRM_unadjusted_selfrep_pheno4_MOA_ORM_residph_standard_06_10.moa

Downstream functional analyses: 

Differentially methylated region (DMRFF) analysis:

Prescription-derived antidepressant exposure:

antidep_pheno1_clean_appt_dmr_res.tsv

Self-report antidepressant exposure: 

selfrep_pheno3_dmr_res.tsv

GO Biological Pathway (msigdbr) enrichment:

Prescription-derived antidepressant exposure:

gtex_v8_ts_DEG_PD.txt

Self-report antidepressant exposure: 

gtex_v8_ts_DEG_SR.txt

SynGo pathway (web-portal) enrichment:

Prescription-derived antidepressant exposure:

syngo_annotations_matching_user_input_PD.xlsx

syngo_ontologies_with_annotations_matching_user_input_PD.xlsx

Self-report antidepressant exposure: 

syngo_annotations_matching_user_input_SR.xlsx

syngo_ontologies_with_annotations_matching_user_input_SR.xlsx

Tissue enrichment (FUMA GENE2FUNC):

Prescription-derived antidepressant exposure:

gtex_v8_ts_DEG_PD.txt

Self-report antidepressant exposure: 

gtex_v8_ts_DEG_SR.txt

Antidepressant exposure methylation profile score (MPS): 

GS_AD_MRS_weights.txt

Source Data:

Source data for Figures and Supplementary Figures which do not represent individual-level data.

source_data.xlsx