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RNA-seq analysis upon ARID1B overexpression

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NIAID Data Ecosystem2026-03-14 收录
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We transduced either an empty vector or ARID1B cDNA in IMR90 cells. Cells were selected with puromycin and 6 days after the infection we collected the RNA. ARID1B is a member of the SWI/SNF chromatin-remodeling complex. Our previous experiments showed that knockdown of ARID1B allows cells to bypass cellular senescence. By performing RNA-seq we have shown that ARID1B expression can induce a set of genes involved in the senescence response. Overall design: 2 samples examined: IMR90 cells expressing an empty vector and IMR90 cells expressing ARID1B cDNA

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2023-01-11
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