R Data Package for "TP53 mutations and TET2 deficiency cooperate to drive leukemogenesis and establish an immunosuppressive environment"

This is an R Data Package with processed data necessary to reproduce the R-based scRNA-seq figures from the manuscript entitled "TP53 mutations and TET2 deficiency cooperate to drive leukemogenesis and establish an immunosuppressive environment".Steps to reproduce selected figures:System RequirementsR v4.4RstudioThis software has been tested on Linux Ubuntu 22.04.5Loading the complete dataset occupies approximately 8 GB memory.2. Installationdownload this object in a convenient location on your system.clone the analysis project to your computer using git clone https://github.com/blaserlab/lapalombella_pu.gitopen the R projecta list of the packages required for the project can be found in library_catalogs/blas02_lapalombella_pu.tsv. Filter for packages with status == "active". Install these packages and their dependencies.install custom packages from our R Universe repository using these commands:install.packages('blaseRtools', repos = c('https://blaserlab.r-universe.dev', 'https://cloud.r-project.org'))install.packages('blaseRtemplates', repos = c('https://blaserlab.r-universe.dev', 'https://cloud.r-project.org'))install.packages('blaseRdata', repos = c('https://blaserlab.r-universe.dev', 'https://cloud.r-project.org'))source R/dependencies.R (the final line in that file must be edited to point to the directory containing the data package)source R/configs.R (the file paths defining the output variables should be customized for your system)see the named files in R/ to reproduce specific figures from the manuscripttypical time required for the first installation and data loading is approximately 15 minutes. This excludes the time required to download the data package.