Directed evolution of SsdA

NIAID Data Ecosystem2026-05-02 收录

蛋白质定向进化

碱基编辑器优化

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1203172 数据链接链接失效反馈

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资源简介：

Targeted deep sequencing data for the analysis of SsdA mutants and the evaluation of their base editing performance.

创建时间：

2024-12-26

Functional Mapping of Protein-Protein Interactions in an Enzyme Complex by Directed Evolution

蛋白质定向进化

酶复合物界面识别

The shikimate pathway enzyme chorismate mutase converts chorismate into prephenate, a precursor of Tyr and Phe. The intracellular chorismate mutase (MtCM) of Mycobacterium tuberculosis is poorly activ

NIAID Data Ecosystem70

Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 17 round 7-2

蛋白质定向进化

晶体结构解析

Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 17 round 7-2

NIAID Data Ecosystem20

Table1_Binding pocket stabilization by high-throughput screening of yeast display libraries.DOCX

蛋白质定向进化

高通量药物筛选

Protein dynamics have a great influence on the binding pockets of some therapeutic targets. Flexible protein binding sites can result in transient binding pocket formation which might have a negative

NIAID Data Ecosystem10

Enhanced base editing by co-expression of free uracil DNA glycosylase inhibitor

碱基编辑器优化

基因编辑精准度

Even the latest generation of base editor (BE3) causes unwanted indels and non-C-to-T substitutions, compromising the fidelity of base editing outcome. Here we report a enhanced base editing system. T

NIAID Data Ecosystem30

PROTein Evolution Using Selection (PROTEUS) [Nanopore]. PROTein Evolution Using Selection (PROTEUS) [Nanopore]

蛋白质定向进化

纳米孔测序

Directed evolution (DE) is a process of mutation and iterative artificial selection to breed biomolecules with new or improved activity. DE platforms are primarily prokaryotic or yeast-based, and stab

NIAID Data Ecosystem20

Directed evolution of SsdA

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