In vitro activity of 57704 and SAHA against class I HDAC isoforms.

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https://figshare.com/articles/dataset/_In_vitro_activity_of_57704_and_SAHA_against_class_I_HDAC_isoforms_/918001 数据链接链接失效反馈

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Data represent the mean ± standard deviation from 3 replicate experiments.

创建时间：

2014-01-29

miRNA expression of lymphoma cell lines with or without HDAC inhibitor treatment

淋巴瘤miRNA表达

HDAC抑制剂

Various types of HDAC inhibitor are now planned or on going to use against non-Hodgkin’s lymphoma including CTCL. However there is a lack of molecular based evidence not only for which HDACi might be

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Computational Exploration of Zinc Binding Groups for HDAC Inhibition

HDAC抑制剂

计算化学药物筛选

Histone deacetylases (HDACs) have emerged as important drug targets in epigenetics. The most common HDAC inhibitors use hydroxamic acids as zinc binding groups despite unfavorable pharmacokinetic prop

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Hydrazide-Based Class I Selective HDAC Inhibitors Completely Reverse Chemoresistance Synergistically in Platinum-Resistant Solid Cancer Cells

癌症耐药性

HDAC抑制剂

In this work, we have synthesized a set of peptoid-based histone deacetylase inhibitors (HDACi) with a substituted hydrazide moiety as zinc-binding group. Subsequently, all compounds were evaluated in

NIAID Data Ecosystem10

Examination of gene expression in human breast cancer cells exposed to the HDAC inhibitor SAHA. Homo sapiens

乳腺癌药物机制

HDAC抑制剂

The identification of proteins that change in response to a drug perturbation can shed light on the molecular mechanisms of the drug and its potential use in therapies. Histone deacetylases (HDACs) ar

NIAID Data Ecosystem70

Receptor-independent ectopic activity of PROLACTIN predicts aggressive lung tumors and indicates HDACi-based therapeutic strategies

癌症分子机制

HDAC抑制剂

Aim: PROLACTIN (PRL), normally produced by the pituitary gland, acts through its receptor (PRL-R) to initiate a signalling cascade to the genome. PRL can also be produced by cancer cells and become on

NIAID Data Ecosystem20

In vitro activity of 57704 and SAHA against class I HDAC isoforms.

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