Supplementary Materials

Supplementary Tables (Table S1: Information on potential targets of 208 P. odoratum active compounds; Table S2: GO functional terms and KEGG enrichment analysis results for the top 2 MCODE network clusters; Table S3: GO functional terms and KEGG enrichment analysis results for 113 potential targets; Table S4: GO functional terms and KEGG enrichment analysis results for 26 targets of levocetirizine acting on pruritus; Table S5: GeneMANIA analysis and GMFA-ED corresponding GO functional terms and KEGG enrichment analysis results; Table S6: Summary of molecular docking scores between P. odoratum targets and those associated with the ErbB signaling pathway and PI3K-AKT pathway. Supplementary Figures (Figure S1: Comparison of KEGG pathway enrichment for pruritus and GMFA-ED in P. odoratum. (A) KEGG analysis of P. odoratum interaction targets intersecting with pruritus. (B) KEGG analysis of pruritus GMFA-ED targets post-GMFA analysis, with significant enrichment in the ErbB signaling pathway; Figure S2: Molecular docking diagrams of MOL010396 with 4drj, 4hjo, 4bqg, and 6e6e proteins, respectively. (A) Binding mode of MOL010359 with the 4drj protein pocket. (B) Binding mode of MOL010396 with the 4hjo protein pocket. (C) Binding mode of MOL010396 with the 4bqg protein pocket. (D) Binding mode of MOL010396 with the 6e6e protein pocket. Interaction forces (a), 2D binding mode (b), and binding pocket (c). ).