Acute Changes in Rat Tissue Gene Expression Following Exposure to Flight Relevant Hypobaria

We exposed healthy, young male rats to different levels of hypobaria (4000 ft or 8000 ft eqiv.) and/or hyperoxia (100% oxygen) for different durations of time (5 or 10 h). We collected heart, lung, brain (hippocampus), and blood tissue samples, processed them for RNA, and performed microarray analysis on the samples.