LNCRNAs and mRNAs in a Gynecological Disease. Homo sapiens

Increasing evidence indicates that long non-coding RNAs (lncRNAs) play important roles in human diseases. This study aimed to investigate the tissue and serum lncRNAs that are differentially expressed between patients with endometriosis, a gynecological disease, to evaluate the potential of these lncRNAs as non-invasive markers for the disease. Genome-wide profiling of lncRNA expression patterns revealed that many lncRNAs were abnormally expressed between sera and tissues of the patient samples. Overall design: the Glue Grant Human Transcriptome Array, which contained approximately 39,223 lncRNAs. The arrays were performed with 5 sets of pooled samples, including a pool of 10 endometriosis serum samples, a pool of 10 control serum samples, a pool of 5 eutopic (EU) endometrium tissue samples, a pool of 5 ectopic (EC) endometrium tissue samples and a pool of 5 negative tissue controls.