Logistic regression odds ratio (and 95%CI) for faster progression* by SNCA Rep1 263bp allele and rs356165 genotypes.

All analyses are adjusted for age at diagnosis (continuous), gender (male/female), smoking status (never/ever), duration of time between PD diagnosis and baseline assessment (in years), and baseline UPDRS motor score.Abbreviations: SNCA = alpha-synuclein; OR = odds ratio; CI = confidence interval; p = p-value; n = number; n.c. = not calculated.Subgroup #1, subjects with off-medication exams only.Subgroup #2, subject with complete UPDRS data at both baseline and follow-up exams.*Faster progression defined as ≥5 point change in motor UPDRS annually.§a P-value for trend was generated using an ordered categorical variable combining the two genetic variants as indicated by the table.