LOCKING INTRAMEDULLARY OSTEOSYNTHESIS IN THE TREATMENT OF DIAPHYSEAL FRACTURES OF LONG TUBULAR BONES: MODERN OPPORTUNITIES, MORPHOLOGICAL BASIS OF REPARATIVE REGENERATION, AND ANALYSIS OF CLINICAL OUTCOMES

This study is devoted to one of the most relevant areas of modern traumatology and orthopedics — the effectiveness of locking intramedullary osteosynthesis (BIOS) in the treatment of fractures of large tubular bones (femur, tibia, and humerus). The article analyzes the mechanisms of post-traumatic bone tissue regeneration, the biomechanical characteristics of BIOS rods, and their effect on intraosseous hemodynamics from a pathomorphological perspective[1,2]. Based on the results of multicenter clinical studies conducted between 2024 and 2026, as well as rehabilitation stages and quality-of-life assessment scales (SF-36, Harris score), the superiority of the BIOS method over traditional treatment techniques is statistically demonstrated.