A structural “toggle” in the RNaseH domain of Prp8 helps balance splicing fidelity and catalytic efficiency
收藏Alliance of Genome Resources2026-08-01 收录
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Purpose: To assess the global impacts of RNaseH domain alleles of Prp8 on the in vivo splice site selection for native introns. Conclusions: Our study reveals functional links between distinct spliceosomal conformations and splicing fidelity.
