Cohesin in AML. Mus musculus

NIAID Data Ecosystem2026-03-09 收录

白血病机制研究

造血干细胞功能

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA306887 数据链接链接失效反馈

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Depletion of Rad21 in murine bone marrow leads to enhanced self-renewal in vitro Overall design: Bone marrow was extracted from mice, infected with lentiviruses encoding shRNAs to Rad21, and cultured in methylcellulose with cytokines for one passage.

创建时间：

2015-12-23

Genome-wide binding of GFI1 in NB4 cells

转录因子结合位点分析

白血病机制研究

ChIP-seq analyses were conducted in NB4 cells with two antibodies against GFI1. Identification of GFI1 binding peaks in acute promyelocytic leukemia derived NB4 cells. Two antibodies against different

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STAT1 is essential for hematopoietic stem cell function and maintains a MHC IIhi stem cell subset that resists myeloablation and neoplastic expansion [LK]

造血干细胞功能

STAT1基因

Adult hematopoietic stem cells (HSCs) are predominantly quiescent and can be activated in response to acute stress such as infection or cytotoxic insults. STAT1 is a pivotal mediator of interferon (I

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Inhibition of DEK contributes to the tolerance of replication stress and restores HSC function in Fanconi anemia (3-CUT-Tag). Inhibition of DEK contributes to the tolerance of replication stress and restores HSC function in Fanconi anemia (3-CUT-Tag)

范可尼贫血机制

造血干细胞功能

Replication stress drives functional decline in HSCs and is a major driver of BM failure in Fanconi anemia (FA). At present, how HSCs respond and counteract replication stress remains largely unknown.

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Global Gene Expression of hematopoietic stem cells expressing endogenous NrasG12D/G12D, NrasG12D/+, Nras+/+. Mus musculus

造血干细胞功能

肿瘤发生机制

Oncogenic NRAS mutations are frequently identified in human myeloid leukemias. In mice, expression of endogenous oncogenic Nras (NrasG12D/+) in hematopoietic cells leads to expansion of myeloid progen

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Expression and function of PML-RARA in the multipotent hematopoietic progenitor cells of Ctsg-PML-RARA mice

急性早幼粒细胞白血病机制

造血干细胞功能

Because PML-RARA-positive acute promyelocytic leukemia (APL) is a morphologically differentiated leukemia, much speculation has been made about whether its leukemic cell of origin might be committed m

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Cohesin in AML. Mus musculus

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