Methylomic Profiling of BDE-47 Effects on Human Placental Cytotrophoblasts. Methylomic Profiling of BDE-47 Effects on Human Placental Cytotrophoblasts

CpG methylomic characterization of BDE-47 exposed cultured primary human cytrophoblasts (2nd trimester) undergoing differentiation in vitro. Overall design: CpG methylome of human villous cytotrophoblasts exposed to BDE-47 or DMSO (vehicle control) for 24h; either exposed after attachment (~3h in culture) or following cell-cell aggregation (~15h). Sample processing and hybridization was performed by the UCSF Gladstone Institute