Data from: Race/Ethnicity Influences Outcomes in Young Adults with Intracerebral Hemorrhage

Objectives: We investigated the predictors of functional outcome in young
patients enrolled in a multi-ethnic study of intracerebral hemorrhage
(ICH). Methods: The Ethnic/Racial Variations in Intracerebral Hemorrhage
(ERICH) study is a prospective multi-center study of ICH among adult (age
≥18 years) non-Hispanic whites, non-Hispanic blacks, and Hispanics. The
study recruited 1000 participants per racial/ethnic group. The present
study utilized the subset of ERICH cases aged <50 years with
supratentorial ICH. Functional outcome was ascertained using the modified
Rankin Scale (mRS) at 3 months. Logistic regression was used to identify
factors associated with poor outcome (mRS 4–6), and analyses were compared
by race/ethnicity to identify differences across these groups. Results: Of
the 3000 ICH cases enrolled in ERICH, 418 were studied (mean age 43 years,
69% male), of which 48 (12%) were white, 173 (41%) were black, and 197
(47%) were Hispanic. For supratentorial ICH, blacks (odds ratio [OR] 0.42,
p=0.046) and Hispanics (OR 0.34, p=0.01) had better outcomes than whites
after adjustment for other factors associated with poor outcome: age,
baseline disability, admission blood pressure, admission Glasgow Coma
Scale score, ICH volume, deep ICH location, and intraventricular
extension. Conclusions: In young patients with supratentorial ICH, black
and Hispanic race/ethnicity is associated with better functional outcomes,
compared with white race. Additional studies are needed to identify the
biological and social mediators of this association.