Antizyme OAZ binds to Ornithine decarboxylase

Antizyme is a non-competitive inhibitor of ODC that is synthesized in response to an increase in polyamine concentration. Tight binding of the antizyme to the ODC monomer forming a heterodimer prevents enzymatic activity. The region of antizyme interacting with ODC is contained in a section involving residues 106–212 in the COOH-terminal half of the antizyme molecule. The induction of antizyme thus leads to a loss of active ODC protein (Pegg, 2006 and references cited in that review). <br>

抗肽酶系ODC的非竞争性抑制剂，其合成是对多胺浓度增加的反应。抗肽酶与ODC单体紧密结合，形成异源二聚体，从而阻止酶的活性。与ODC相互作用的抗肽酶区域位于抗肽酶分子COOH末端半部分的残基106-212区域。因此，抗肽酶的诱导导致活性ODC蛋白的减少（Pegg, 2006及该综述中引用的参考文献）。