Ligand-Gated Ion Channel Database

The Ligand-Gated Ion Channel database provides access to information about transmembrane proteins that exist under different conformations, with three primary subfamilies: the cys-loop superfamily, the ATP gated channels superfamily, and the glutamate activated cationic channels superfamily. The development of the Ligand-Gated Ion Channel database was started in 1994, as part of Le Novère's work on the phylogeny of those receptors' subunits. It grew into a serious data resource, that served the community at large. However, it is not actively maintained anymore. In addition, bioinformatics technology evolved a lot over the last two decades, so that scientists can now generate quickly customised databases from trustworthy primary data resources. Therefore, we decided to officialy freeze the data resource. The resource will not disappear, and all the information and links will stay there. But people should not consider it as an up-to-date trustable resource. For any new work, they should consider using alternative sources, such as UniProt, Ensembl, Protein Databank etc.

配体门控离子通道数据库提供对存在于不同构象下的跨膜蛋白信息的访问，该数据库包含三个主要亚家族：半胱氨酸环超家族、ATP门控通道超家族以及谷氨酸激活的阳离子通道超家族。配体门控离子通道数据库的构建始于1994年，是勒·诺韦尔关于这些受体亚基系统发育工作的组成部分。它逐渐发展成为一个重要的数据资源，为整个科学界提供服务。然而，该数据库目前已不再进行活跃维护。此外，生物信息学技术在过去二十年中也经历了显著的发展，使得科学家们能够快速从可信的原始数据资源中生成定制化的数据库。因此，我们决定正式冻结这一数据资源。该资源将不会消失，所有信息和链接都将保留。但人们不应将其视为一个最新的可信赖资源。对于任何新的研究工作，他们应考虑使用替代来源，如UniProt、Ensembl、蛋白质数据库等。