Detection of circRNA biomarker for Acute Myocardial Infarction based on system biological analysis of RNA Expression. Detection of circRNA biomarker for Acute Myocardial Infarction based on system biological analysis of RNA Expression

A series of system biological analysis are performed on RNA expression to find new effective circRNA biomarkers for AMI. Firstly, the expression level of circRNA in blood samples of patients with AMI and those with mild coronary stenosis are compared to reveal circRNAs which are involved in AMI. Then, circRNAs which are significant expressed abnormally in the blood samples of patients with AMI are selected from those circRNAs. Overall design: Abnormal expression of circRNAs often affects the occurrence and development of diseases. In order to discover the circRNA related to acute myocardial infarction (AMI), the expression levels of circRNAs in blood samples of patients with AMI are firstly analyzed and compared with the expression levels of circRNAs in patients with mild coronary artery stenosis to find abnormally expressed (up-regulated or down-regulated) circRNAs.