Chromatin immunoprecipitation and sequencing for the H3K27me3 histone mark was performed on livers of male mice either treated with vehicle or with TCPOBOP for 27 h. This dataset is part of a larger s

NIAID Data Ecosystem00

Supporting data for “HDAC9 Regulates Macrophage Polarization and Modulates the Progression of Intrahepatic Cholangiocarcinoma”

肝内胆管癌免疫微环境

表观遗传调控

How tumor-related epigenetic abnormalities affect the interactions between cancer cells and the immune system is still not fully understood. Tumor genome studies have revealed that chromatin modifiers

Figshare2025-07-28 更新00

DNMT3A Reads and Connects Histone H3K36me2 to DNA methylation [RNA-seq]

表观遗传调控

甲基化反应机制

DNA methylation at the 5-position of cytosine (5mC) is a crucial epigenetic mark in regulating biological processes including gene silencing, gene imprinting, and X chromosome inactivation. It has lon

NIAID Data Ecosystem00

Multiple Nucleosome Positioning Sites Regulate the CTCF-Mediated Insulator Function of the H19 Imprinting Control Region†

表观遗传调控

染色质绝缘子功能

The 5′ region of the H19 gene harbors a methylation-sensitive chromatin insulator within an imprinting control region (ICR). Insertional mutagenesis in combination with episomal assays identified nucl

PubMed Central00

Histone deacetylation and cytosine methylation are required for the normal compartmentalization of heterochromatin

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