Proline as Lewis Base Catalyst: Diastereoselective Synthesis of Isoxazoline-<i>N</i>-oxide through [3 + 2] Cycloaddition
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资源简介：
A catalytic cascade synthesis of isoxazoline-N-oxide was developed through proline-catalyzed nitroalkene activation. A large substrate scope was obtained with good to excellent yields. Mechanistic studies revealed intramolecular cyclization as the rate-determining step, giving only trans isomers in all cases.
创建时间：
2008-09-18
