Enantioselective Syntheses of Furan Atropisomers by an Oxidative Central-to-Axial Chirality Conversion Strategy

For
the first time, enantiomerically enriched atropoisomeric furans
have been accessed using a central-to-axial chirality conversion strategy.
Hence, oxidation of the enantioenriched dihydrofuran precursors gave
rise to axially chiral furans with high enantiopurities accounting
from excellent conversion percentages (cp) in most cases.

首次，通过中央至轴向手性转换策略，成功获取了手性富集的顺反异构体呋喃。因此，对手性富集的二氢呋喃前体的氧化作用，产生了轴向手性呋喃，其手性纯度极高，这在大多数情况下归因于卓越的转化率（cp）。