OPLS-DA coefficients and their variable importance in projection (VIP) for significantly changed metabolites in serum.

aCoefficient values are calculated by LED-BPP coefficient-coded loadings plots.bCoefficient values are calculated by CPMG coefficient-coded loadings plots.cMulti-criteria assessment (MCA) was performed by followed criteria: 1. Coefficient value |r| >0.576, 2. VIP>1, 3. p value dThe coefficients from the OPLS-DA results; positive and negative signs indicate positive and negative correlations in the concentrations of serum metabolites.eIndependent t test (two-tailed).HDL: high-density lipoprotein; LDL: low-density lipoprotein; PUFA: Polyunsaturated fatty acids; UFA: unsaturated fatty acids.