Predictive performance of the model compared to NetMHCIIpan as measured by AUC0.1 and AUC.

The balanced set was used to identify the optimal weights for RSA and coil combined with rescaled binding affinities (Rescaled01) as define by Eq. (1). The optimal α-values for each model are given in the table. P-values are given by paired t-tests when comparing AUC0.1 of the model to the NetMHCIIpan method. Rest of training set refers to the training set, and test to the 697 ligands in the test set.