ReactIR Monitoring of Turbo-Hauser Base Formation Enables a Robust Iodination Reaction During an Early Scale-Up Campaign

We required a robust, reliable method to form the Turbo-Hauser base TMPMgCl·LiCl during an early scale-up campaign to support the synthesis of key intermediate 1 within our Discovery Process team. We report herein our investigations with ReactIR and kinetic modeling to better understand the formation of the Turbo-Hauser base on scale, resulting in the successful application of our optimized protocol to enable the preparation of the target building block on the decagram scale.