The differential metabolic response to trans-4-hydroxyproline by Clostridioides difficile and commensal Clostridia

Clostridioides difficile is a bacterium that infects the gut and causes severe diarrhea and inflammation. This study was designed to understand how the ability to utilize the nutrient trans-4-hydroxyproline affects the fitness of C. difficile and how the availability of trans-4-hydroxyproline affects C. difficile and selected commensal Clostridia