Median levels of analytes (pg/ml) and ranges (in parenthesis), and accuracies in the diagnosis of TB disease in all study participants.

Participants were not stratified according to Quantiferon results or HIV status prior to analysis. All analytes that showed significant differences (P<0.05) or trends according to the Mann Whitney U test are shown. Analytes that discriminated between TB disease and no TB disease with AUC ≥0.70 after ROC analysis are highlighted in bold. Cut-off values were determined based on the highest likelihood ratio. Sensitivity and specificity are expressed as a percentage. AUC = Area under the ROC curve, 95% CI = 95% confidence interval.
$N = unstimulated marker levels, Ag = Antigen stimulated levels, Ag-N = the difference between the antigen stimulated and the unstimulated responses; ♯At the cut-off value used in the QFT-IT test (0.35 IU/ml = 14 pg/ml [60]), the sensitivity of IFN-γ for TB disease was 79.0 (54.4–93.9) and specificity was 50.9 (37.3–64.4).