Published Orthogonal Replication, Independent External Asymmetry, Structural and Ontology Support, and a Five-World Assay Bridge of a Native Fracture-State Family in a Computational Longevity Discovery Pipeline (Trinity Claims #87-#138, 2026-03-30)
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This version fixes the next mature external-validation milestone from the Trinity computational longevity-discovery pipeline. Claims #87-#138 establish an exact operational plateau for native fracture-state admission, orthogonal replication of the target TOP3A/RMI2/CCDC69 family in published huMAP3 layers, strong-core switch decomposition, exact same-core response algebra, a strict falsification protocol, an exhaustive assay scorecard, universal external quartet visibility, canonical stable scaffold convergence, independent external asymmetry across BioGRID and CORUM, orthogonal functional validation in DepMap, a structural outsider-support layer in human RCSB, a reviewed ontology outsider-support layer in UniProt GO Cellular Component, and a final five-world assay bridge. Across BioGRID, CORUM, DepMap, RCSB, and UniProt GO Cellular Component, the target is the only analyzable family that passes every target-facing bridge gate, yielding world_pass_count = 5 while all non-target families remain at 0. This package contains the milestone reports, claim documents, source notes, extracted evidence tables, source files, and publication materials for the first five-world bridge from computational fracture-state discovery to a directly assayable experimental expectation. This is a computational discovery and preregistration package and not a completed causal validation study.



