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DNA repair factor recruitment after Cas9-mediated DSBs using the 'very fast CRISPR' system
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创建时间：
2020-03-12
相关数据集
NHEJ-mediated repair of CRISPR-Cas9-induced DNA breaks efficiently corrects mutations in HSPCs from patients with Fanconi Anemia. Roman-Rodriguez et al
The raw data of the main figures can be obtained here.
NIAID Data Ecosystem80
File S2.zip
Annotated sequence files in .ape format (comparable with Genbank) of knock-ins generated by CRISPR/Cas9-mediated genome editing. Unmodified genomic sequence is also provided.
Figshare2023-03-14 更新20
CRISPR RNA-seq from K562 (ENCSR929YET)
RNA-seq on K562 cells treated with a CRISPR gRNA against AIMP1. (AIMP1-BGKcLV26) For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Re
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Discovery of Isaindigotone Derivatives as Novel Bloom’s Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair
Homologous recombination repair (HRR), a crucial approach in DNA damage repair, is an attractive target in cancer therapy and drug design. The Bloom syndrome protein (BLM) is a 3′–5′ DNA helicase that
NIAID Data Ecosystem40
Rationally designed miCas9 mediates gene editing
In this study, we report the development of meticulous-integration Cas9 (miCas9) by fusing a minimal motif consisting of thirty-six amino acids encoded by BRCA2 Exon 27 (Brex27) to spCas9. In comparis
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