Palladium-Catalyzed Construction of Tetracyclic Scaffolds via the 1,7-Enyne Carbocyclization/Iodophenol Dearomatization Cascade

An efficient palladium-catalyzed
dearomatizing [2+2+1] carbocyclization
of 1,7-enynes with iodophenols has been developed. A type of tetracyclic
scaffold was built in this reaction, exhibiting a broad substrate
scope with moderate to excellent yields. More importantly, this method
provides a potential strategy for the synthesis of tetracyclic skeleton
natural products.