Expression profile of knockdown of Bfar in MFC cells

E3 ligase is widely reported to exert fundamental functions in cancers. In this study, we aimed to explore the functions and mechanisms of crucial E3 in gastric cancer. We carried out systemic bioinformatic analyses of public-available gastric tumor datasets to search for potential therapeutic targets in E3 ubiquitin ligases, revealing the E3 ligase BFAR as the essential factor for gastric cancer proliferation. Targeting BFAR inhibited gastric cancer proliferation in vivo in nude and especially immunocompetent mice.