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Formal Nucleophilic Substitution of Bromocyclopropanes with Azoles

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NIAID Data Ecosystem2026-03-09 收录
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A highly diastereoselective protocol for the formal nucleophilic substitution of 2-bromocyclopropylcarboxamides with azoles is described. A wide range of azoles, including pyrroles, indoles, benzimidazoles, pyrazoles, and benzotriazoles, can be efficiently employed as pronucleophiles in this transformation, providing expeditious access to N-cyclopropyl heterocycles.

创建时间:
2016-02-21
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