Fumarate hydratase (FH) mutations predispose to renal cysts cancer. These cancers overexpress hypoxia-inducible factor-alpha (Hif-1a). We have generated a conditional Fh1 (mouse FH) knockout mice that

NIAID Data Ecosystem50

Additional file 3 of Moderate exercise-induced dynamics on key sepsis-associated signaling pathways in the liver

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生物医学研究

Additional file 3. File S4: MetaScope- CytoHubba analysis (Hub genes)-Excel file.

DataCite Commons2024-08-14 更新70

IL-10 signaling remodels adipose chromatin architecture to limit thermogenesis and energy expenditure [ChIP-Seq]

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脂肪组织功能

Signaling pathways that promote adipose tissue thermogenesis are well characterized, but the physiologic limiters of energy expenditure are largely unknown. Here we show that ablation of the anti-infl

干细胞与再生医学数据中心2022-02-20 更新70

Amplification of RANK- and c-Met-mediated signaling promotes metastatic colonization

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