Neuroprotective activities of <i>AID</i> genes <i>in vivo</i>.

A quantitative analysis of the Fluoro-Jade C staining in the CA1 area of the hippocampus of non-injected and control-injected animals and animals stereotaxically injected with rAAVs expressing AID genes. The Fluoro-Jade C signal obtained without and with kainate treatment in the hippocampus of both the injected and the non-injected side is expressed as a percentage of control, i.e. the average kainate-induced Fluoro-Jade C signal obtained from the non-injected hemispheres of kainate treated animals (for details see Methods). The mean±SEM is given; compared to control condition ‘saline plus kainate’, each AID gene significantly reduced the Fluoro-Jade C signal (t-test; **p<0.01; ***p<0.001).