Table of variants tested, as well as observed human ACE2 variants near the SARS-CoV-2 spike interface.

Descriptions of column titles: pmid—Pubmed ID of publication describing control variants; rationale—rationale for why the variant was included in the study; position—amino acid positions in the ACE2 protein; snv—“yes” indicates that the variant can be created through single nucleotide variation from the human ACE2 sequence; _allele_freq—allele frequency of the variant in the database, _homozygotes—number of homozygous samples of the variant found in the database; _hemizygotes—number of hemizygous males with the variant found in the database; sars_cov2_infection—geometric mean of the normalized SARS-CoV-2 pseudovirus infection values observed in our experiments. (TSV)