Table_3_Effects of Active Upper Limb Orthoses Using Brain–Machine Interfaces for Rehabilitation of Patients With Neurological Disorders: Protocol for a Systematic Review and Meta-Analysis.doc

Introduction: The field of brain–machine interfaces (BMI) for upper limb (UL) orthoses is growing exponentially due to improvements in motor performance, quality of life, and functionality of people with neurological diseases. Considering this, we planned a systematic review to investigate the effects of BMI-controlled UL orthoses for rehabilitation of patients with neurological disorders.Methods: This systematic review and meta-analysis protocol was elaborated according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P 2015) and Cochrane Handbook for Systematic Reviews of Interventions. A search will be conducted on Pubmed, IEEE Xplore Digital Library, Medline, and Web of Science databases without language and year restrictions, and Patents Scope, Patentlens, and Google Patents websites in English, Spanish, French, German, and Portuguese between 2011 and 2021. Two independent reviewers will include randomized controlled trials and quasi-experimental studies using BMI-controlled active UL orthoses to improve human movement. Studies must contain participants aged >18 years, diagnosed with neurological disorders, and with impaired UL movement. Three independent reviewers will conduct the same procedure for patents. Evidence quality and risk of bias will be evaluated following the Cochrane collaboration by two review authors. Meta-analysis will be conducted in case of homogeneity between groups. Otherwise, a narrative synthesis will be performed. Data will be inserted into a table containing physical description, UL orthoses control system, and effect of BMI-controlled orthoses.Discussion: BMI-controlled orthoses can assist individuals in several routine activities and provide functional independence and sense of overcoming limitations imposed by the underlying disease. These benefits will also be associated with orthoses descriptions, safety, portability, adverse events, and tools used to assess UL motor performance in patients with neurological disorders.PROSPERO Registration Number: CRD42020182195.

引言：由于运动性能、生活质量及神经疾病患者功能性的提升，脑机接口（BMI）在上肢（UL）矫形器领域的应用正呈指数级增长。鉴于此，我们计划进行一项系统综述，以探究BMI控制的UL矫形器对神经疾病患者康复的影响。方法：本系统综述及荟萃分析方案根据《系统综述与荟萃分析优先报告项目》（PRISMA-P 2015）和《Cochrane干预措施系统综述手册》进行编制。搜索将在PubMed、IEEE Xplore数字图书馆、Medline和Web of Science数据库进行，不设语言和年份限制，并在英语、西班牙语、法语、德语和葡萄牙语的语言范围内对专利范围、Patentlens和Google Patents网站进行搜索，时间跨度为2011年至2021年。两位独立的审稿人将纳入随机对照试验和准实验研究，使用BMI控制的主动UL矫形器以改善人类运动。研究必须包含年龄大于18岁、被诊断为神经疾病且上肢运动功能受损的参与者。三位独立的审稿人将对专利进行相同的审查程序。证据质量和偏倚风险将按照Cochrane协作网的标准由两位审稿人进行评估。若组间同质性存在，则将进行荟萃分析；否则，将进行叙述性综合。数据将被插入包含物理描述、UL矫形器控制系统和BMI控制矫形器效果的三维表中。讨论：BMI控制的矫形器可以帮助个体完成多项日常活动，提供功能性独立感和克服潜在疾病限制的成就感。这些益处亦将与矫形器的描述、安全性、便携性、不良事件以及用于评估神经疾病患者上肢运动表现的工具相关。PROSPERO注册号：CRD42020182195。