Crystal structure of RIP1 kinase in complex with DHP77
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Crystal structure of RIP1 kinase in complex with DHP77 Descriptor: Receptor-interacting serine/threonine-protein kinase 1, [(5~{S})-5-[3,5-bis(fluoranyl)phenyl]pyrazolidin-1-yl]-[1-(5-methyl-1,3,4-oxadiazol-2-yl)piperidin-4-yl]methanone Authors: Thorpe, J.H, Campobasso, N, Harris, P.A. Deposit date: 2019-03-25 Release date: 2019-05-01 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase. J.Med.Chem., 62, 2019
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2019-03-25
