TBX3的丢失增强了人类多能干细胞[肝母细胞RNA-seq]产生胰腺祖细胞的能力
收藏干细胞与再生医学数据中心2023-02-10 更新2024-03-06 收录
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资源简介：
Tbx3 regulates liver development in the mouse, but it's role in human liver development is unclear. We generated TBX3 knockout pluripotent stem cell lines and found that liver differentiation is also impaired in humans. Interestingly we noted expression of pancreas-specific genes during the liver differentiation in the TBX3 knockout line. To further investigate this phenomenon, we performed RNA-seq on cells at the hepatoblast stage of the liver differentiation. These studies demonstrated that the loss of TBX3 enhances pancreatic-gene signature, implicating TBX3 as a regulator of fate decisions.
创建时间：
2023-02-10
