Mutants with defects in cilia structure were resistant to ethosuximide toxicity.

∞Animals cultured at 20°C were classified as normal (+) or defective (Dyf) for amphid neuron dye filling (see Materials and Methods).#Experiments were done with 12 mg/ml ethosuximide. The differences in percent resistance between che-3 alleles were not statistically significant except that che-3(am162) was significantly different from che-3(am178), che-3(am165) and che-3(e1124) (posm-3 alleles were not statistically significant except that osm-3(p802) was significantly different from osm-3(am161) and osm-3(am177) (p.†The dye-filling phenotype of these mutants was described previously [28].*These values may underestimate the fraction of animals that were resistant to ethosuximide, since we observed multiple animals that were mature, indicating they were ethosuximide resistant, but they were desiccated on the side of the dish and not included in the data. We have observed that mutants with severe chemotaxis defects have a propensity to leave the agar surface.