TNKS inhibition in APC/CTNNB1 mutant organoids. Mus musculus strain:C57Bl/6

NIAID Data Ecosystem2026-03-11 收录

Wnt信号通路调控

肠道类器官药物响应

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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA524289 数据链接链接失效反馈

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TRanscriptional effects of TNKS inhibition in mouse intestinal organoids carrying different APC and CTNNB1 mutations

创建时间：

2019-02-26

Expression data from Control or TRIB3-silenced HCT-8 cells. Expression data from Control or TRIB3-silenced HCT-8 cells

结直肠癌分子机制

Wnt信号通路调控

To determine the critical mediator of TRIB3-enhanced Wnt/beta-catenin signaling, we examined the expression profile of genes that might regulate Wnt/beta-catenin by using mRNA microarrays. Aberrant ac

NIAID Data Ecosystem60

TGFÃ-induced lncRNA LINC00313 activates Wnt signalling and promotes cholangiocarcinoma progression

胆管癌分子机制

Wnt信号通路调控

Cholangiocarcinoma (CCA) is a devastating liver cancer characterized by high aggressiveness and resistance to therapy, which results to poor prognosis. Signals imposed by oncogenic pathways, such as t

NIAID Data Ecosystem50

Activation of Wnt Signaling by Chemically Induced Dimerization of LRP5 Disrupts Cellular Homeostasis

Wnt信号通路调控

肿瘤发生机制

Wnt signaling is crucial for a variety of biological processes, including body axis formation, planar polarity, stem cell maintenance and cellular differentiation. Therefore, targeted manipulation of

Figshare2016-01-18 更新40

Importance of RAD6B in activation of canonical WNT signaling in melanoma development

黑色素瘤分子机制

Wnt信号通路调控

We have demonstrated that RAD6B, a ubiquitin conjugating enzyme that is a principal component of translesion synthesis pathway, stabilizes and transcriptionally activates beta-catenin by lysine 63-lin

NIAID Data Ecosystem60

Wnt signaling promotes cell caudalization and inner ear differentiation in mouse stem cell-derived organoids

类器官分化

Wnt信号通路调控

Multiple time points and doses of Wnt activation were sampled. Data showed that precise Wnt modulation promote the cell caudalization and inner ear differentiation single cell RNA-sequencing data were

NIAID Data Ecosystem50

TNKS inhibition in APC/CTNNB1 mutant organoids. Mus musculus strain:C57Bl/6

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