Pharmacokinetic parameters of metabolite SB-553253 following single and multiple once daily dosing of darapladib enteric coated tablet 160 mg.

a Values are expressed as geometric mean (% between subject coefficient of variation) b Values are expressed as median (range) c In the majority of subjects the concentrations of SB553253 were generally not quantifiable for a sufficient duration of time to calculate t½ Cmax = maximum plasma concentration; Tmax = Time of occurrence of Cmax; AUC(0-τ) = Area under the concentration-time curve over the dosing interval; AUC(0-∞) = Area under the concentration-time curve from time zero (pre-dose) extrapolated to infinite time; t1/2 = Terminal phase half-life; Cτ = Pre-dose (trough) concentration; NA: Not applicable; N = Number of subjects SB-553253 to Darapladib Cmax and AUC(0-τ) ratios are also presented.