The mutational landscape of cancer's vulnerability to ionizing radiation

Individual variant or wild type gene expression after constitutive transduction in immortalized lung ephithelial cells (BEAS-2B). The hypothesis is that variant gene expression is associated with radiation resistance or sensitivity. The results provide transcriptomic information on genes variants that conferred radiation resistance or sensitivity. Overall design: Total mRNA obtained from BEAS2B cells transduced with the indicated gene variants and their corresponding wild type alleles.